Mercedes W221-S Key Replacement Guide

Last updated: August 2026 · Verified OEM part numbers

Quick answer: The Mercedes W221-S (various model years) uses the CGDI MB 08 Version Changeable Frequency 3 Button Keyless Go Smart Key for Mercedes W164 W221 W216 2005-2010 — verified against OEM part numbers. See the full compatibility table below.

Compatible keys for Mercedes W221-S

Before you order

• Match the year range — Mercedes changed key systems across model years. Check your registration year.
• Check your current key — the OEM number printed on your key matches the table above.
• Programming — smart keys need a compatible programmer (Xhorse, VVDI, Autel). We can advise which one works for each key.

Frequently asked questions

Which key fits my Mercedes W221-S?

The Mercedes W221-S (various model years) uses the CGDI MB 08 Version Changeable Frequency 3 Button Keyless Go Smart Key for Mercedes W164 W221 W216 2005-2010. Check the table above for all compatible options, verified against OEM part numbers.

Do you supply Mercedes W221-S keys wholesale?

Yes. We supply locksmiths and key distributors at wholesale prices with MOQ from 5 units. Message us on WhatsApp for today's price list.

Can a Mercedes W221-S key be programmed without the dealer?

In most cases yes, using tools like Xhorse, VVDI or Autel. We can advise the right programmer for each key SKU.

Related: All Mercedes keys · All guides · Key Finder

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